Calliope (pronounced ka-LYE-ah-pee) Joy Carr, nicknamed Cal, is the youngest child of Pat Carr and Maria Kefalas. Cal was diagnosed with late-infantile onset metachromatic leukodystrophy at the age of 2. Cal is now 10 years old and receives hospice care at home. Because of her amazing nurses and doctors, she laughs and smiles every day.

In 2013, Cal’s brother, PJ, had the idea to sell cupcakes to raise money and help the doctors find a cure for "Cal's disease." Since then, we have sold 45,000 cupcakes and raised more than $840,000 through Cal's Cupcake Challenge, The Cupcake 5k, and The Cupcake Gala. Cal's Cupcakes helped establish the nation's first Leukodystrophy Center of Excellence at the world-renowned Children's Hospital of Philadelphia. Cal and the cupcake have been featured in the Philadelphia Inquirer, The Huffington Post, Slate, and CBS Sunday Morning with Jane Pauley.


We believe "cupcakes can change the world."

The Calliope Joy Foundation is a charitable non-profit organization with 501(c)(3) status and all gifts are tax deductible


“We understand that our daughter Cal will not benefit from the work we do, but we are grateful for playing a small role in changing what means to have leukodystrophy and offering hope to the families who come after us. The promise of gene therapy to cure Cal's disease has given us a front-row seat to the biggest medical breakthrough in a generation.”

– Maria Kefalas, co-founder, The Calliope Joy Foundation

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Mailing Address: 

The Calliope Joy Foundation

PO Box 2866

Bala Cynwyd, PA 19004


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The Calliope Joy Foundation - Cals Cupca